Carmody Laboratory

IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health.

Jaffery H, Huesa C, Chilaka S, Cole J, Doonan J, Akbar M, Dunning L, Tanner KE, van 't Hof RJ, McInnes IB, Carmody RJ, Goodyear CS.

Arthritis and Rheumatology 2023

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Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells.

Somma D, Kok FO, Kerrigan D, Wells CA, Carmody RJ.

Frontiers in Immunology 2021

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Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data.

Kok FO, Wang H, Riedlova P, Goodyear CS, Carmody RJ.

Cellular Signalling 2021 

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The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits.

Mitxitorena I, Somma D, Mitchell JP, Lepistö M, Tyrchan C, Smith EL, Kiely PA, Walden H, Keeshan K, Carmody RJ.

Journal of Biological Chemistry 2020

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CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis.

Sarrou E, Richmond L, Carmody RJ, Gibson B, Keeshan K.

International Journal of Molecular Sciences 2020

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The IκB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus.

Collins PE, Somma D, Kerrigan D, Herrington F, Keeshan K, Nibbs RJB, Carmody RJ.

Proceedings of the National Academy of Sciences U S A. 2019 

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The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80.

Smith EL, Somma D, Kerrigan D, McIntyre Z, Cole JJ, Liang KL, Kiely PA, Keeshan K, Carmody RJ.

Nucleic Acids Research 2019

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IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function.

Ridgley LA, Anderson AE, Maney NJ, Naamane N, Skelton AJ, Lawson CA, Emery P, Isaacs JD, Carmody RJ, Pratt AG.

Frontiers in Immunology 2019

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Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis.

Anderson AE, Maney NJ, Nair N, Lendrem DW, Skelton AJ, Diboll J, Brown PM, Smith GR, Carmody RJ, Barton A, Isaacs JD, Pratt AG.

Rheumatology 2019 

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Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages.

Butcher SK, O'Carroll CE, Wells CA, Carmody RJ.

Frontiers in Immunology 2018

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A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling.

Salomé M, Magee A, Yalla K, Chaudhury S, Sarrou E, Carmody RJ, Keeshan K.

Cell Death and Disease 2018

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NF-κB and the Transcriptional Control of Inflammation .

Mitchell JP and Carmody RJ.

Int Rev Cell Mol Biol 2018

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Regulation of NF-κB by PML and PML-RARα.

Ahmed A, Wan X, Mitxitorena I, Lindsay AJ, Paolo Pandolfi P, McCaffrey MW, Keeshan K, Chen YH, Carmody RJ.

Scientific Reports 2017

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The Regulation of NF-κB Subunits by Phosphorylation.

Christian F, Smith EL, Carmody RJ. 

Cells 2016 

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The Ubiquitination of NF-κB Subunits in the Control of Transcription.

Collins PE, Mitxitorena I, Carmody RJ. 

Cells 2016 

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Glycolysis and pyrimidine biosynthesis are required for replication of adherent-invasive Escherichia coli in macrophages.

Thompson AP, O'Neill I, Smith EJ, Catchpole J, Fagan A, Burgess KE, Carmody RJ, Clarke DJ.

Microbiology 2016

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Bcl-3 in CD4+ T Cell-Mediated Rheumatoid Arthritis Pathogenesis: Comment on the Article by Meguro et al.

Pratt AG, Anderson AE, Carmody RJ, Isaacs JD.

Arthritis Rheumatol 2016

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Modulation of NF-κB Signaling as a Therapeutic Target in Autoimmunity.

Herrington FD, Carmody RJ, Goodyear CS.

J Biomol Screen 2016

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Mapping the Interaction of B Cell Leukemia 3 (BCL-3) and Nuclear Factor κB (NF-κB) p50 Identifies a BCL-3-mimetic Anti-inflammatory Peptide.

Collins PE, Grassia G, Colleran A, Kiely PA, Ialenti A, Maffia P, Carmody RJ.

J Biol Chem 2015

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The Regulation of Endotoxin Tolerance and its Impact on Macrophage Activation.

Collins PE, Carmody RJ.

Crit Rev Immunol 2015

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Control of NF-κB subunits by ubiquitination.

Collins PE, Colleran A, Carmody RJ.

Methods Mol Biol 2015

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Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.

Ning Z, McLellan AS, Ball M, Wynne F, O'Neill C, Mills W, Quinn JP, Kleinjan DA, Anney RJ,Carmody RJ, O'Keeffe G, Moore T.

Hum Mol Genet 2015

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Inhibition of transcription by B cell Leukemia 3 (Bcl-3) protein requires interaction with nuclear factor κB (NF-κB) p50.

Collins PE, Kiely PA, Carmody RJ.

J Biol Chem 2014

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Identification of a unique hybrid macrophage-polarization state following recovery from lipopolysaccharide tolerance.

O'Carroll C, Fagan A, Shanahan F, Carmody RJ.

J Immunol 2014

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Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse.

O'Carroll C, Moloney G, Hurley G, Melgar S, Brint E, Nally K, Nibbs RJ, Shanahan F, Carmody RJ.

Clin Exp Immunol 2013 

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Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription.

Colleran A, Collins PE, O'Carroll C, Ahmed A, Mao X, McManus B, Kiely PA, Burstein E, Carmody RJ.

Proc Natl Acad Sci U S A 2013